Expression Of MMP-7, TIMP-1, Survivin And Ki-67 In Adenomyosis And Their Clinical-pathological Significance

Objective: To investigate the expression of matrix metalloproteinase-7(MMP-7), tissue inhibitor of matrix metalloproteinase-1(TIMP-1), Survivin and Ki-67 in eutopic endometrium, ectopic endometrium of adenomyosis and normal human endometrium in order to study the function and relativity of invasion ,apoptosis and proliferation in the course of adenomyosis . Its early clinical diagnosis and the treatment application are discussed.Method: Specimens of normal endometrium , eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis were obtained for immunohistochemical MMP-7 , TIMP-1, Survivin and Ki-67. Results:1. The expression of MMP-7 in eutopic endometrial tissue and ectopic endometrial tissue of adenomyosis was significantly higher than that of normal endometrium(P<0. 05). The discrepancy was mainly reflected in secretory phase. TIMP-1 in normal endometrium was expressed significantly higher than eutopic endometrial tissue and ectopic endometrial tissue of adenomyosis (P<0. 05). The correlation between the expression of MMP-7 and TIMP-1 in normal endometrium was negative (P<0.05), while no correlation had been found in eutopic endometrial tissue and ectopic endometrial tissue of adenomyosis(P>0. 05). 2. The expression of Survivin in ectopic endometrium of adenomyosis was significantly higher than that of normal endometrium and eutopic endometrium of adenomyosis, as it was seen mostly in proliferative phase(P<0.05). No significant diferences between the eutopic endometrium of adenomyosis and of normal endometrium were observed (P>0. 05). There...