The Research On The Polymorphism Of CYP2E1,GSTM1 And The Susceptibility Of Bladder Cancer

Objective:This research intends to evaluate the relationship between CYP2E1, GSTM1 polymorphisms and the susceptibility of primary bladder cancer of the people in Jilin Province, China.It will provide scientific evidences for carrying out effective and exact individual prevention, early diagnosis and early treatment of susceptible people.It will also provide the genetic theoretical support for the treatment of primary bladder cancer.Materials and Methods:We adopted epidemiological questionnaire and PCR-RFLP to obtain the necessary information and determine the genotypes of CYP2E1 and GSTM1 of primary bladder cancer patients and health controls.We analyzed the relationship between the single or multiple risk factors and the susceptibility of primary bladder cancer using Chi-Square test and Multiple Logistic Regression analysis.Results:The distribution of different CYP2E1 genotype in people with primary bladder cancer does not differ from that in the health control, but the distribution of the null GSM1 genotype in people with primary bladder cancer significantly differs from that in the health control. Smoking is a risk factor of bladder cancer,as smoking is significantly correlated to the occurrence of bladder cancer. Joint analysis shows that people carrying both wild type of CYP2E1 and null type of GSTM1 have a significantly high occurrence of bladder cancer.Conclusion:CYP2E1 wild type genotype can enhance the occurrence of bladder cancer in people that carry the null genotype of GSTM1. Smoking is another risk factor of bladder cancer. People with null genotype of GSM1 should be considered as susceptible population of bladder cancer.