Quantification Of Left Ventricular Function In Patients With Early Type 2 Diabetes Mellitus Using Real-time Three-dimensional Echocardiography

Diabetes mellitus is a progressive metabolic disease that is emergingas a global epidemic. The prevalence of diabetes increases year by yearwith the development of economy,changes of lifestyle and increasingaging population.Long duration of metabolic disturbances causes vascular and neural damage , leading to macrovascular(coronary artery disease,cerebrovascular disease,peripheral vascular disease) , microvascular (nephropathy ,retinopathy),and europathy complications. Many conventional risk factors have been shown to be important contributors to the development of diabetic.These condition including insulin resistance,impaired fasting glucose,impaired glucose tolerance,and diabetes mellitus can result in the risk factors of cardiovascular disease. Diabetic heart disease has higher incidence of mortality. Coronary heart disease (DHD) include diabetes mellitus,specificness cardiomyopathy,coronary heart disease(CHD),hypertensive heart disease(HHD) The abnormity of metabolism in diabetes mellitus could cause arterial dysfunction,which meantthe long-term Hyperglycemia, hyperlipemia and insulin resisitance could cause atherosclerosis easily. At the cell level,diabetes mellitus changed the Functions of various cells,including endothelial cells,smooth muscle Cells and platelets,which all suggest blood vessel's structure and function disorder.In order to find the heart dysfunction earlier,we utilize Pulsed doppler echocardiography of traditional as while as real-time three-dimensional Echocardiography to assess left ventricular systolic synchronicity to evaluate the patient's globle and segmental left ventricular function who have T2DM. By this method ,we can provide a reliable evidence for early diagnosis and treatment of DHD. Philips IE33 and Q-Lab software were used in this study on 41 patients with T2DM and 46 normal cases.The result shows that there were no statistical significance between two group of left ventricular EF by traditional ECG,but cann't exclude left ventricular pseudo normalized,2.There were statistical significance between two group of left ventricular EF by RT3DE; 3.There were statistical significance in research about synchronism of the cardiac muscle. Traditional ECG cann't reflect if patient's left ventricular functionwho have Type 2 Diabetes mellitus have changed in the earlier period,but RT3DE,left vent ricular systolic synchronicity can find the change of globle and segmental left ventricular function in earlier period T2DM,and RT3DE in evaluating left ventricular systolic synchronicity are sensitive,specific and accurate method.As a revolutionary ultrasonic technology,RT3DE allows easy and fast data acquiring and analyzing. It is providing clinicians a new method in assessing the global and regional left ventricular function and left ventricular mass with its feasibility,accuracy and good repeatability. RT3DE is a landmark in the development of ultrasound. We believe that the limits of RT3DE will be got over and RT 3DE will be the routine method for assessing cardiac function in the immediate future.