Assessing Blood Supply Of Primary Hepatic Carcinoma With Diffusion-weighted MR Imaging And Dynamic Contrast MR Imaging

Objective: To assess the blood supply of primary hepatic carcinoma with diffusion-weighted MR Imaging and dynamic dontrast MR imaging.Materials and Methods:55 primary hepatic carcinoma cases which were approved by clinical diagnosis were classfied relatively hypervascular PHCs and relatively hypovascular PHCs by mean contrast enhancement ratio with dynamic dontrast MR imaging. Then diffusion-weighted MR Imaging with different b values and measurement of apparent diffusion coefficient were performed in 55 PHC cases. ADC of lesion , liver, spleen, kidney and gallbladder were measured in every case.Rusluts: On DWI with small b value and small b value remainder, ADC were affected by blood perfusion of leison. The mean ADC of hypervascular PHCs( 3.71×10ˉ3mm2/s ) was significantly higher than that of hypovascular PHCs (2.18×10ˉ3mm2/s) with small b values (b1=1.6 s/mm2, b2=55 s/mm2). The mean ADC of PHCs was not evidently affected by large b values and large b values remainder (b1=50s/mm2, b2=400 s/mm2 ,b3=800 s/mm2). ADCs of the lesions and organs become more steady and relialbe with the b value added.Conclusions: ADC of PHCs on DWI with small b values were affected by blood perfusion and were nearly correlated with mean contrast enhancement ratio with dynamic dontrast MR imaging. DWI and ADC with small b values can reflect the blood supply of PHC. ADC of PHCs on DWI with large b values were relative steady .PHC would be accurately diagnosis using ADC with large b value . PHC was diagnosis qualitatively and quantificationally by small and large b values.