The Sedative Effect Of Fentanyl On Ventilated Patients In Intensive Care Unit.

Objective: To evaluate the sedative effect of fentanyl on ventilated patients in intensive care unit (ICU).Method: 30 orotracheal intubated and mechanical ventilated medical patients in intensive care unit were randomly divided into two groups. Midazolam(Group M) or midazolam combined with fentanyl (Group M+F, 100:1) was continuously intravenous infused to achieve a target MAAS (Motor Activity Assessment Scale) of 3 and ventilator synchrony score of ATICE (Adaptation to the Intensive Care Environment) ≥3 after loading dose of midazolam. The sedation level was evaluated and the infusion rate was adjusted every 2 hours to maintain the target sedation goal and the hemodynamic, respiratory and sedative parameters were recorded at the same time. The oxygenation index were obtained at 12 and 24 hours. The infusion was ceased until 24 h and then the sedative degree was assessed every 30 minutes until MAAS ≥3, and the recover time was obtained. Result: There was no significant difference in BP, oxygenation index and adjustive frequency of drugs between the two groups (P > 0.05). The heart rate, respiratory rate and pressure of airway in Group M+F were decreased significantly than those in Group M (P < 0.05). The amount of midazolam used and cost of sedatives were less than those in group M(P < 0.05). Satisfactory degree of sedation or ventilator synchrony and awakeness score...