Exploration Of P21-Activated Kinase 5 Cellular Function In Periodontal Diseases

BACKGROUND: Protein phosphorylation is involved in most of important cellular events such as metabolism, transportation, adhesion, growth, development, apoptosis, muscle contraction, immocyte activation, nerve activity and tumor genesis. Protein phosphorylation orchestrates key aspects in multiple cell transduction and cellular signaling pathways, and it can regulate reversible processes through their ability of two reverse components: protein kinases mediated phosphorylation and protein phosphatase mediated diphosphorylation. Protein kinase is a kind of phosphate transferase, and it can transfer γ-phosphate residue of ATP to the specific amino acid residue of substrate and phosphorylated protein, then exert the biological function.