Effect Of Artemisiae Annuae CQ-189 On Inhibitory Proliferation And Induced Differentiation Of Human Leukemia Line (K562)

Objective: Leukemia is a malignant hematopoietic tumor which threatens the health of humanity. Up to now, traditional chemotherapy and radiotherapy are still the main methods to treat leukemia. But they have many sides effect and ratio of relapse is very high, especially, it greatly damages the immunity and hematopoiesis. So, finding nature effective ingredients extracted from Chinese Traditional Medicine, which has both higher effective and lower poisonous, has become the polular topic in research of anti-tumor drug now.Artemisiae annuae is compositae plant, artemisinin is the anti- malaria active principle which is separated from the leaf of artemisiae annuae, it has marked anti-malaria function, but it's toxicity is small. The research confirmed that artemisinin has the better functions of anti-malaria and anti-tumor et al pharmacological functions. Up to date, there is no research that artemisinine derivative inhibit the proliferation of leukemia cells and induced their differentiation.The human erythroleukemia K562 cells is a low-differentiated blast cell with differentiating potentialities towards...