The Potassium Channel Gene Expression Of Myocardial Sleeves Of Pulmonary Veins And Effects Of Amiodarone On The Potassium Channel Gene Expression In Rabbits With Rapid Atrial Pacing

AIM: The purpose of this study was to investigate the potassium channel gene expression of myocardial sleeves of pulmonary vein and amiodarone's effects in rabbits with rapid atrial pacing.METHODS: Rabbits were divided into three groups, including (1) the control group (n=10) with sham operation and placebo, (2) the right atrial pacing(RAP, n=12) group at 600 beats/min with the placebo, and (3) the amiodarone group(n=10) with both oral amiodarone at 100 mg· kg^-1 · d^-1. and RAP simultaneously for seven days. The messenger ribonucleic acid (mRNA) of the specimen was measured by reverse transcription-polymerase chain reaction.RESULTS: (1) Compared with the control group, mRNA levels of Kv4.3 (transient outward K⁺ current, I_to1) in the RAP group were reduced by 45%(P<0.01) following seven days of RAP, and that in the amiodarone group by 51%(P<0.01) than that of the RAP group. (2)mRNA gene expression of Kir6.2 (inward rectifier inhibited by ATP, I_KATP) was upregulated by 32% in RAP group (P<0.01) than that of the...