| Objective: To evaluate the effect of function and configuration of sciatic nerve and muscle in rat with chronic alcoholism and study the relevant mechanism.Methods: Twenty-four rats were divided randomly and equally into 3 group : group A(control group), group B(ethanol group) and group C(exercise group) . The group B and C group was administered ethanol (50%, v/v)8ml·kg-1·day-1 in 8 weeks .The control group was administered isovolume normal saline. Meanwhile, at the last 2 week . The rats of the rehabilitation group was administered with swimming training and running in the net hole. Measurements of weight and appetite in each rat were performed every week and the electromyography and histomorphometric analysis in sciatic nerve for peripheral neuropathy were evaluated in 24 rats which were exposed to ehtanol or control condition for 8 weeks.Result: (1). Both weight and appetite decreased in group B and group C than group A. (2). Electrophysiologically group B showed low amplitude of compared with group A and group C significantly. (3). In histomorphometrical studies, HE in light microscope showed axonal degeneration with secondary segmental demyelination in group B.Conclusions: 1. Long term alcohol intake can damage the function and Configuration of peripheral nerve sural muscle in rat which is similar to that in human alcoholics . 2. The exercise training can improve the functional recovery of extremities in rats with...
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