| Objective: inadequate myocardial protection in patients undergoing open heart surgery contributes to overall hospital morbidity and mortality. For this reason, new pharmacologic agents are under investigation to protect the regionally and globally ischemic heart. The purpose of this srudy is to observe the clinical effects of cardioplegia with adenosine in cardiopulmonary bypass.Methods: In a randomized prospective study, 38 patients with open heart surgery were divided in two groups: adenosine group and control group. Adenosine group(experiment group, n=18)received exogenous adenosine in cardioplegia solution, control group (n=20) did not receive adenosine. Blood samples were taken to determine the serum concentrations of CK-MB and cTn-I before cardiopulmonary bypass, 2h,6h and 16h after aortic dec lamp, meantime clinical data including duration of ventilator support, time to... |
PDF Full Text Request