Molecular Epidemiology Study Of Interaction In Bladder Cancer Susceptibility Gene Polymorphisms And Environmental Factors

ObjectiveTo evaluate the relationship between CYP2E1 and GSTM1 genetic polymorphism and bladder transitional cell cancer susceptibility among Han people in China.MethodsThe study population consisted of 252 histologically confirmed bladder transitional cell carcinoma cases and 320 controls without previous and current history of cancer or systemic diseases in China from 2002 to 2005, In a hospital-based case-control study,Subjects completed a questionnaire during a personal interviews to collect detailed informations on demographic factors ,medical history ,lifetime tobacoo and alcohol use ,and occupational exposure,and so on. PCR was used to identify CYP2E1 and GSTM1 genotypes and restriction enzyme Rsa I was used to identify a specific point mutation of CYP2E1.ResultsBetween bladder cancer patient group and normal control group CYP2E1 genetic polymorphisms did not show a significant differences in frequency distribution differences(p=0.714) , but that of GSTM1-null did a statistical difference(P = 0. 006) OR = 1.89 (1.28—4.40) .