The Relations Of Gene Polymorphisms Of ENOS And Fâ…¦ With Coronary Heart Disease In Henan Han Population

BackgroundEpidemiologic studies have shown that hyperilipidemia , hypertension , cigarette smoking , diabetes mellitus and family history of cardiovascular disease are the risk factors for coronary heart disease(CHD) . Although the accumulation of coronary risk factors often leads to CHD , however , there is a population of patients without such classic risk factors who develop coronary heart disease . CHD may arise from interactions between environmental and genetic factors in general,but the precise mechanism by which CHD occurs remains to be elucidated.Nitric oxide (NO) synthesized by endothelial NO synthase plays a key in vascular regulation and atherosclerosis . Studies suggest the basal release of NO by the endothelium contributes to basal vascular tone and regulates blood flow and blood pressure . NO also inhibits the proliferation of smooth muscle cell . Furthemore , NO protects against platelet aggregation and inhibits platelet adhesion to vascular endothelium . In addition ,NO inhibits leukocyte adhesion to endothelium . All of these processes are important events during atherogenesis . Dysfunction of this important mechanism may promote atherosclerosis . Several studies haver reported polymorphism of the eNOS gene are associated with CHD . Thus the eNOS gene is considered to be an important gene for CHD.Factor VII(FVII) is the first enzyme in the extrinsic pathway of the blood...