The Analysis Of Correlation Between ApoE Gene Mutations And Lipoprotein Glomerulopathy

[Background and Objective]Lipoprotein glomerulopathy (LPG) is a unique renal disease characterized by lipoprotein thrombus-like substances in markedly dilated glomerular capillaries and high plasma concentration of apolipoprotein E(apoE). It was originally described in 1989 by Saito et al. So far more than 60 cases have been reported, more than 20 cases of them from China. All patients were of Asian ancestry but 2 cases.To date the pathogenesis of LPG is still unknown. Japanese researchers found apoE mutations in some Japanese LPG patients, including apoE Sendai (Argl45ProX apoE Kyoto(Arg25Cys), apoE Tokyo(141-143-0), apoE Maebashi(142-144-0)and apoE(156-173-0). Accordingly, it was hypothesized that lipoproteins containing mutant apoE may induce the specific glomerular lesions in LPG To elucidate the etiological role of apoE gene mutations in LPG, they transduced apoE Sendai into apoE knockout mice using an adenovirus vector and established an experimental animal model for LPG It further demonstrated that apoE gene mutation is associated with LPG However, the apoE mutations were also found in the patients' relatives who did not develop LPG Few researchers found no mutations in LPG patients, so they thought apoE gene mutation is not related to LPG Chen et al analyzed apoE gene in 3...