The Effect Of Dl-butylphthalide On Cognitive Ability And GFAP,MBP Of Aged Rats After Chronic Cerebral Hypoperfusion

Background and objectiveResearch on ischemic cerebrovascular diseases is an essential component of neuroscience field. Many studies from domestic and foreign countries have focused on acute ischemic brain impairment for many years, but it is insufficiency and not deep enough for research in cognitive ability after chronic cerebral hypoperfusion. Chronic ischemic brain impairment is a common pathological state, always complicated in many diseases such as vascular dementia, Binswanger disease, Alzheimer disease and so on. In the early stages, its cardinal manifestation is cognitive disorder. At last, it can cause eternal or progressive impairment of cognitive and neurological function. With the ratio of senile increasing in our country, prevention and treatment to diseases mainly from chronic cerebrovascular is more and more important.Overwhelming numbers of studies have proved that comprehensive loss of neurons and white matter lesions resulting from chronic cerebral ischemia can cause cognitive disorder. Neurons in cortex and hippocampus are such important parts of nervous system involved in learning and memory that loss of them can lead to impairment of learning and memory. The changes happening after white matter lesions from chronic cerebral ischemia include decreasing of oligodendrocyte, increasing of astrocyte and microglia. Astrocytes are the most numerous of all nerve cells composed of nervous system, accounting for 50...