The Expression Of Skp2 And P27～(kip1) In Gastric Carcinoma And Its Relationshiop With Its Clinical Pathology

Background and objective: Gastric carcinoma (GC) that does harm to human health is one of common malignant tumours.It is difficult to diagnose GC in early stage which is usually advanced as we detect it.The fatality rate of gastric carcinoma is comparativly high and it is one of leading causes of cancer death. Its occurrence is not clear at present, carrying out the research of its pathogenesy and clinical therapy is a fundamental way to lessen its harm. As well as the others malignant tumor, its occurrence and development is a process that many genes and many factors participate together. A dynamic succession process involves in activation of many oncogenes and deactivation of many anti-oncogene and changes of cellular biological behaviour.Various kinds of genes interact and co-participate occurrence and development of neoplasma,while its occurrence has close relationship to disorder of cell cycle.S-phase kinase associated protein 2(Skp2) is a mumber of F-box protein family and a kind of ubiquitin joining enzyme. As substrate of SCF Complex ,its main function is to identify subunit, i.e, to identify and degradate phosphorylation substrate specifically, then accelerate the process of cell cycle. Skp2 plays an important role in DNA duplicating, transcription and cell multiplication. Research reveals that many regulative protein is degradated by SCF ubiquitin joining enzyme complex. p27^kip1 is a cell cycle depended kinase inhibitor, It regulates cell cycle negatively and is mainly degradated through ubiquitin proteasome pathway which is mediated by Skp2.