The Expreession Of Sialy Lewis-～X In Human Gastric Adenocarcinoma Tissues

Background and Objective:Gastric cancer is one of the most common malignant neoplasms in China.Actually the multidisciplinary therapies of gastric cancer include surgery,chemotherapy and immuntity therapy.The effect,however, has not shown a significant improvement.The main reason of death is invasion and metastasis of tumor. Tumor metastasis is a complex process involved in multimolecule The sialyl Lewis-X antigen plays an important role in the process of human gastric adenocarcinoma. metastasis.The sLe~x antigen was one of discovered strucrally related to oligosaccharides structures carbohydrate antigens expressed in tumer cells and embryonic tissues recently. There are several lines of evidence showing that sLe~x is responsible for the adhension of human cancer cells to endothelium.E-selectin and Mucin-1(Muc-1) present on endothelial cells mediates these interactions. sLe is known to particepate in the processes of leukocyte infiltration during in inflammation and mediate the adhesion of...