Effects Of Fluoroquinolone Antibiotics AX On Electrophysiological Activities In Guinea Pig Cardiac Myocytes

Fluoroquinolones antibacterial are widely used alternatives to β-lactam agents in the treatment of many bacterial infections. Their antimicrobial activity results from a selective antagonism between host DNA and bacterial DNA without interfering with eucaryotic topoisomerases. The early quinolones, from the early 1960s, had a limited spectrum of antibacterial activity, mainly against gram-negative pathogens. Further observations of structure-related increases in activity, changes in pharmacokinetic characteristics, and reduced toxicity were followed by numerous chemical modifications of the quinolone molecule.The widespread use of the fluoroquinolones has raised the question of the cardiac safety of these medications. Currently it was reported that fluoroquinolones antibacterial have been associated with risk of QT prolongation and arrhythmias following administration to humans. Furthermore, it has been shown the mechanisms underlying prolongation of the cardiac action potential is mainly related to blockade of delayed rectifier K~+ channel.It was evidence that sparfloxacin, a broad-spectrum fluoroquinolone antibiotic is capable of prolongation of cardiac action potential duration (APD) in the isolated rabbit Purkinje fiber, guinea-pig papillay muscle, and elongating QT interval in dogs ECG, indicating a potential cardiac toxicity. AX is a new member of fluoroquinolone antibactic with uncertain features synthethized by our own country. In order to...