Donepezil Attenuated The Inhibition Of Beta-amyloid Peptide On The Expression Of Beta2-nicotinic Acetylcholine Receptors Of Hippocampus Neurons

Alzheimer's disease(AD), the most common form of dementia in adults, is a neurodegenerative disorder characterized by selective neuronal loss and the presence of two different types of fibril deposits: senile plaques(SP) and neurofibrillary tangles(NFT). The epidemic study showed that the incidence of AD is around 5% — 10% which brought a great burden to the society. Till now its etiological factors are still not very clear. Scientist supposed that there were some hypotheses about it, such as A|3 cascade themry, choline hypothesis and gene theory. Among those hypotheses, Aβ cascade theory was more and more recommended. The core of senile plaques is mainly composed of an amyloid β-peptide(Aβ). Nicotinic acetylcholine receptors (nAChRs) are a multigene family of ligand-gated ion channels, nAChRs in the brain are important for functional processes, including cognitive and memory functions. Consistent losses of nAChRs have been measured in vitro in autopsy brain tissue of Alzheimer's disease patients.Donepezil is a new reversible acetylcholinesterase inhibitor...