Experimental Study On The Inhibitory Effects Of Antisera Induced By IgE Synthetic Peptides On Asthma

Objective: Immunoglobulin E (IgE) is vital to hypersensitivity disease such as asthma and allergic rhinitis. It is now well established that the development of atopic diseases, such as asthma, is linked to circulating concentrations of IgE. Once an antigen enters the host, it is subject to that host's immune system. The immunoglobulins are used when the antigen encounters one of the host's B-cells. Synthesis of IgE after exposure to allergen is the instigator of the allergic process. IgE is just one player in a highly complex immune response by Th2 cells, it is undoubtedly of central importance in both immediate hypersensitivity and the late-phase responses characteristic of allergy and asthma. IgE bound to mast cells via Fc ε RI triggers degranulation and release of mediators that produce symptoms associated with allergy. The IgE/FceRI interaction is a target for clinical intervention in allergic disease. Using chimeric proteins, the C ε 3 was indicated as the principal region in mouse IgE involved in the interaction with Fc ε RI. The small domain...