The Expression Of BAG-1, BCL-2 And P53 In Human Retinoblastoma Detected With Tissuearray

BackgroundRetinoblastoma (RB) is a malignant tumor originated from the retinal cells of the eye, which is the most common eye tumor in the children. RB is fatal and harmful to the visual acuity, if it is not properly treated. Therefore, early diagnosis and treatment is critical in saving lives and preserving visual function. It is widely accepted that the pathogenesis of retinoblastoma is the retinoblastoma gene (RB gene) inactivation, but there are more and more anti-apoptosis factors are found in retinoblastoma tissues. This suggests that anti-apoptosis factors play a role in the development of retinoblastoma.It has been proved that bag-1 is a multi-functional anti-apoptosis factor, and it is associated with bcl-2 and p53 closely. In many kinds of malignant tumors, such as breast cancer, carcinomas of stomach and cervices, it could be seen over expression. However, there are no reports on the relationship of bag-1 and retinoblastoma.Tissue array is made of a great number of micro tissues arrayed regularly on a microscopy slide. It can be used with high efficacy, fast, low cost, high...