Effect Of Hyperphosphorylated Tau Protein And Hypercholesteremia On The Expression Of β-Amyloid

Background:Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by neuronal loss and the formation of neuritic plaques, neurofibrillary tangles (NFTs), and neuropil threads.In recent 10years,lots of scholars support the hypothesis of amyloidrthe overexpression of Ap can lead to neurofibrillary tangles, further can lead to neuronal apoptosis and synapse disfunction.But we can not deplete the possible that the hyperphosphorylated tau protein can increase the expression of Ap.So the relation of hyperphosphorylated tau protein and Ap may not be simple;The cholesterol, or cholesterol metabolism, plays a role in the pathophysiology of AD. Cholesterol levels can modulate the enzymatic processing of the amyloid precursor protein (APP) and Ap production. Neurotoxic of amyloid can lead to neuronal apoptosis and show dementia in clinical.Objective:To explore the effect of hyperphosphorylated tau protein and hypercholesteremia on the expression of β- amyloid .