The Role Of Heat Shock Protein 70 And Its Significance To Early Diagnosis Of Acute Rejection In Liver Transplantation

In the postoperative period after liver transplantation, a common complication is the acute allograft rejection that has been the death cause to the recipient and the most important causation to the failure of allograft. It has been an obstacle which has puzzled organ transplantation ever since. Its mechanism has not been clear until now and the method to early diagnosis of acute rejection has not yet been found since the diagnosis of the rejection has still depended on pathological biopsy. But the allograft is often seriously damaged before histological change appears. In recent years, however, it has been discovered that Hsp70 is correlative extensively with immunoreaction. The role of Hsp70 in immunoreaction has been paid more attention to because of its immune regulation and activation of some cytokines. The aim of the present study is to improve the model of rat orthotopic liver transplantation to observe the development of acute rejection after operation and investigate the...