Effects Of The Gene Of Microtubule-associated Protein 2 On Proliferation And Invasion Of Malignant Melanoma

BackgroundMalignant melanoma(MM) occurs in the melanocytes,nevus cells. It is a serious form of skin cancer. Malignant melanoma not sensitivity to actinotheraphy and chemotherapy and because of the limited success of surgical therapy in treating melanoma, the search of effective systemic therapy for melanoma has generated intense interest over the years. In recent years, with the rapid development of molecular biology technology, gene therapy of malignant melanoma has given a new hope for patients.Melanocytes arise from the neural crest and they are known to exhibit certain characteristics of other neural crest derivatives. For example, nerve cell has dendrite, melanocytes also have many dendrites. Similarly, melanocytes have the neural protein markers of nerve cell inherent. Microtubule-associated protein 2 is one of these. That microtubule- associated protein 2 is expressed abundantly in radial growth phaseand vertical growth phase melanoma cell line, but MAP2 was not detectable in metastatic melanoma.. So we conjecture that the expression of microtubule-associated proteins 2 maybe have relations with proliferation and invasion of malignant melanoma and study it.ObjectiveTo explore the biological effects of the gene of microtubule-associated protein 2 on growth of malignant melanoma.Materials and Methods:...