The Study On The Relations Between Inflammatory Cytokines And S100 Protein In Infants' Serum After Cardiopulmonary Bypass

Objective: Cerebral injury related to cardiopulmonary bypass (CPB) is one of the main complications after intracardiac surgery. The severe one could develop to death. Evident brain injuries are mostly caused by embolism, intracranial hemorrhage or various kinds of accidents. However, with the advance in technical competence, such injuries obviously declined. Nowadays, more and more infants with low weight, complicated malformation receive operation in early age. Therefore great attention is devoted to the correlation between inflammatory response and cerebral injury. Systemic inflammatory response stimulated by CPB that is one kind of unphysiologic circulation can do toxic damage on cerebral tissue. Such injuries mostly demonstrate subclinical process. Infant's center nervous system (CNS) that is immature and differs from adult brain remarkably is easier injured. But these injuries can be reversible, if being monitored and interfered in early stage. It is difficult to inspect infant during the period of CPB for the effect of ventilation and sedative. Furthermore the specific characteristics of infant neurological examination and the difficulty to perform examinations such as CT, MRI, and EEG et al are also disadvantages. The neuroproteins S-100 released into the circulation are suggested to be reliable and sensitive biochemical markers for primary brain damage. The study was designed to test the serum levels of cytokines(TNF-α,IL-6,IL-8) and S-100 during the CPB. The objective is to investigate the trend of these targets and the correlation between inflammatory response in infant CPB and subclinical cerebral injury.Methods: 40 infants no more than 3 years old with acyanotic...