The Short-term Effects And The Influence To Cytokine Of Cardiac Resynchronization Therapy In Patients With Congestive Heart Failure

Background and objectives: Congestive heart failure(CHF)is predicted as the 21st century's puzzle of cardiovascular domain suffering about 22.5 million people all over the world. Patients with heart failure New York Heart Association (NYHA) cardiac function Class IV have a reported 1-year mortality of 33 to 37 percent. According to the Framingham Heart Study, the 5-year mortality for patients with congestive heart failure is 75 percent in men and 62 percent in women.Going through the pathophysiologic research of CHF, the heart remodeling induced by hemodynamic disorder and the activation of neuro-endocrine regulation was believed the main links among the occurrence and development of heart failure, and the chronic activation of cytokines plays an important pathophysiologic role in depressing myocardial contractility and aggravating heart remodeling. Large scale, random and double-blind clinical researches have proved that the use of neurohormone antagonist, such as angiotensin converting enzyme inhibitor, beta-blocker and aldosterone antagonist, can resist the progression of heart failure, and resisting cytokines to treat heart failure is being noticed now. In recent years, many abroad studies confirmed that cardiac resynchronization therapy(CRT)could correct the hemodynamic disorder and improve clinical symptoms of the patients with heart failure. But the mechanism of its improving heart function is still not clear completely. It hasn't been reported whether CRT can affect cytokine network up to now.The aim of this study is to observe the short-term (three months after therapy) effect of CRT in patients with congestive heart failure, to...