Combined Effect Of Blast Wave And Hypoxia On The Inner Ear Of Guinea Pig

Objective:Blast injury (BI) is always one of the main subjects of medical research. With the flying development and service of new explosive weapons (such as: FAE) and multi-function weapons and the increase of explosive accidents in airtight or relative airtight space, blast-hypoxia combined injury on the inner ear are increasing beside blast injury. Therefore, the researches of blast-hypoxia combined injury on the inner ear are becoming important. The objective of the study is to set up an animal model by BST-I bio-shock tube and hypoxia cabin, that can accurately express the characteristics of the blast-hypoxia combined injury on the inner ear in the early stage of injury, observe the characteristics and law of blast-hypoxia combined injury on the inner ear, and provide theoretical basis for the precaution, diagnosis, treatment and grading of blast-hypoxia combined injury.Methods:1.Establishment of guinea pig models with blast-hypoxia combined injuries: 64 guinea pigs were averagely divided into four groups randomly, ie, normal control group (NCG), hypoxia injury group (HG), blast injury group (BG) and blast-hypoxia combined injury group (BHG). The guinea pigs in NCG were not inflicted. The guinea pigs in HG were placed into the hypoxia-cabin, where the mixed gases of 10% oxygen concentrations were given. The guinea pigs in group BG were inflicted with blast injury by the bio-shock tube with blast wave overpressure for 50.0 kPa. After blast injury, the guinea pigs in the group were put into the hypoxia-cabin immediately, and the mixed gases of 10% oxygen concentrations were given. The mortality, rates of respiration and so on were observed at the 6th hour after injury.2. Characteristics of the guinea pig's inner ear blast-hypoxia combined injury in the early stage: 64 guinea pigs were averagely divided into four groups randomly, ie, normal control group, hypoxia injury group, blast injury group and blast-hypoxia combined group. Hearing thresholds of guinea pigs were assessed with auditory brainstem response (ABR). The...