The Experimental And Clinical Investigation Of The Effect Of Disconnection Of Pyloric Sphincter By Finger Pressing In Gastric Emptying Function

Background: Esophageal carcinoma is comparatively common malignant tumor in our country. Surgical resection is still the main therapeutic tool. To gain more excellent therapeutic efficacy, majorities of scholars assert to lengthen resected esophagus and perform high-position esophagogastrostomy in recent years. With the number of high-position esophagogastrostomy increasing, gastric emptying disorder has already become one of more common postoperative complications. To prevent the disorder, traditionally, intraoperative pyloroplasty or pyloromyotomy is often adopted. However, They may result in dumping syndrome and duodenogastric reflux. To solve the problem, disconnection of pyloric sphincter by finger pressing (DPF) has been used in cardiac carcinoma by some surgeons and has been confirmed that it can not only facilitate gastric emptying but also resist duodenogastric reflux. DPF has also been adopted in esophageal carcinoma by some other surgeons and has been reported that it can facilitate gastric emptying. But strict investigation about the application in esophageal carcinoma has not been reported by now. Therefore, it has very important clinical value to investigate the effect of DPF in thoracic gastric emptying function after esophageal carcinoma resection with high-position esophagogastrostomy.Objective: To explore the value and the possible mechanisms of DPF in thoracic gastric emptying after esophageal carcinoma resection with high-position esophagogastrostomy, the animal experiments have been employed to investigate the injury and healing of the local place undergone DPF and the effect of DPF in the pyloric pressure of dogs undergone bilateral truncal vagotomy, and the clinical investigations have been employed to observe the effect of DPF in the pyloric pressure and postoperative gastric emptying and duodenogastric reflux of patiens undergone esophageal carcinoma resection with high-position esophagogastrostomy.