The Relationship Between Invasiveness And Expression Of Galectin-3 And Ki-67 In Human Pituitary Adenomas

Background:Pituitary adenoma is one of the most common intracranial benign tumors (about 10%), which ranks the third in intracranial tumors with the incidence rate about 1/100000~ 7/100000. It's called "sub clinical adenomas", which is discovered in the autopsy. Its incidence reached 10%. It's most common in early or middle adult age (20-40 years old). There's no significant between male and female. Generally speaking, pituitary adenomas with characteristics of localized growth and without metastasis have good prognosis after surgery. But some of pituitary adenomas have malignant potential, such as invasive growth, destroy the bone, invade the dural, nerve, cavernous sinus and blood vessel widely and could not be removed completely, therefore, the therapy effect is relative limited. The invasion of adenomas is one of the most important reasons of its recurrent. With the progress of molecular biology, some scholars studied the pituitary adenomas from cell to molecular level, to interpret the biological behavior, guide the therapy and predict the prognosis, meanwhile, to provide guidance for the medication. Some previous studies showed that Gal-3 expressed in several tissues of normal and cancers. The expression of Gal-3 could be implicates cell growth, adhesion, apoptosis, angiogenesis, tumor invasion and metastasis. The Ki-67 antigen is a protein present in the nuclei of cells in the phase of proliferation. Its expression is a marker of the cell in mitosis. Thus, this could reflect the proliferation and invasiveness of the cell. Invasive pituitary adenomas have some characteristics that are familiar with malignant tumors. The forms of normal and adenoma cell are difficult to recognize using normal histological-pathological method. Therefore, it's significant to study the expression of Gal-3 and Ki-67 antigen in pituitary adenomas and could provide a molecule marker of pituitary adenomas invasiveness.Objective:In our study, we observe the expression of the Gal-3 and Ki-67 antigen in invasive...