Effect Of Diabetes Mellitus On The Periodontal Tissues Of Rats During Orthodontic Tooth Movement

Objective: As a common metabolic disorder, Diabetes mellitus (DM) has about 20 million suscepts with a rapid growth over the past years, whose standardized morbidity rate is 3.21% in China and whose suscepts become younger than before. Type I Diabetes mellitus usually starts from adolescent, whose morbidity rate is about 83 ppm and still increases. With the increase of morbidity of DM deformities of teeth and mandible, and the improvement of living standard, more and more suscepts of DM request orthodontic therapy. But few clinical reports can be found due to the affection of DM on tooth and jawbones. Establishing rat type I Diabetes mellitus tooth movement model and observing the periodontal remodeling during orthodontic tooth movement in DM rats, this research focuses on exploring orthodontic tooth movement therapy for the earlier period of DM to provide a fundamental experiment theory.Method: Eighty male (6-8 weeks of age) Sprague-Dawley rats (weight from 200 to 220g) were used in this study. The animals were randomly divided into two groups with 40 rats each, the control group (normal tooth movement group) and the experiment group (DM tooth movement group), and divided...