The Studies Of Adenovirus-mediated HSV-TK/GCV Suicide-gene Therapy Controlled By HTERT Promoter In Animal Models Of Human Bladder Cancer

Objective: Malignant tumor has become the first or second cause which leads to die of mankind. And bladder cancer is the most common malignant tumor in urinary system. It ranks as the eighth morbidity in all of the malignant tumors. The main characteristic of bladder cancer is easy to recur and transfer. Many cancers recur and the majority of patients with advanced cancer eventually succumb to the disease, and therapy of invasion bladder cancer is a tough problem. Gene therapy has extensive application prospect because it can restore the characteristic genovariation of tumor tissue or it can urge tumor cell to death. With the construction of high performances elective administration carrier or detection of some original objective gene, gene therapy had become the fourth method in the treatment of cancer followed by surgery, radiotherapy and chemotheraphy. The HSV-TK and its product have high affinity for acyclovir and its analogues, including ganciclovir, mainly producing the phosphorylated product. Subsequent modification by the host cell to a triphosphorylated form and incorporation during replication halts growth of the developing DNA strands...