Neurohomonal Changes In Patients Who Underwent Transcatheter Closure For Congenital Heart Disease

Objective To investigate the neurohomonal changes in patients with congenital heat disease and the effect of transcatheter closure on neurohomonal activities by comparing the levels of neurohomonal factors before and after the procedure.Methods 100 patients with congenital heart disease (CHD group) including 70 ones have undergone transcatheter closure and 30 healthy control subjects (NC group) were selected for the study. Concentrations of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1), Angiotensin II (Ang II), aldosterone (ALD), and norepinephrine (NE) were assayed in patients and controls by immunoradiometric assays (RIA) or enzyme linked immunosorbent assay (ELISA). Blood samples for analysis were collected from the patients before the closure and 24 h, 1 month, 3 month, and 6 month after the closure respectively.Results (1) All the levels of ANP, BNP, ET-1, AngII, ALD, and NE in CHD group before the closure were apparently higher than those in NC group (P﹤0.01). (2) The levels of ANP, BNP, ET-1, AngII, ALD, and NE in all CHD subgroups (divided by heart function) before the procedure showed highly significant stepwise increases and were also significant higher than those in NC group (P﹤0.01). (3) The levels of ANP, BNP, ET-1, AngII, ALD, and NE in CHD group at 24 h after the procedure had no statistical difference from those before the procedure, whereas gradually declined from 1 month after the closure(P﹤0.05 between 24 h and 1 month; rest P﹤0.01), and returned to normal level in 6 month after the procedure (P﹥0.05 versus control).