The Effect Of Hypotensive Resuscitation With 7.5% Sodium Chloride In Uncontrolled Hemorrhagic Shock After Massive Splenic Injury

Objective: We studied the effect of permissive hypertensive resuscitation with 7.5% sodium chloride on the blood lost and survival time in rats in uncontrolled hemorrhagic shock after massive splenic injury.Methods: 33 healthy Sprague dawley male rats were divided into 4 groups in randomized block design: sham-operation group (SO group, n=6), untreated group (NF group n=9), 0.9% sodium chloride group (NS group n=9), 7.5% sodium chloride (HS group n=9).SO group: After arteriopuncture and venipuncture, a midline laparotomy was performed. And then the laparotomy incision was closed with a running suture. NF group: After arteriopuncture and venipuncture, MSI model was produced, MSI untreated. NS group: Initiated treating MSI with 0.9% saline when the MAP reached 40mmHg.By adjusting the rate of transfuse kept MAP at 60±5mmHg,top rate at 100 ml kg-1 h-1. .HS group: Initiated treated MSI with 7.5% hypertonic saline(HTS) when the MAP reached 40mmHg, By adjusting the rate of transfuse kept MAP at 60±5mmHg,top rate at 10ml kg-1 h-1.Results: blood loss and the amount of fluid resuscitation: The total blood loss and mean blood loss rate of NS group is significantly higher than the other groups (P<0.05).The total blood loss of HS group is higher than NF group, but no statistical differences on the mean blood loss rate. The amount of infusion of HS group is significantly lower than NS group (P<0.05). The survival time of HS group and NS group is significantly longer than NF group (P<0.05), but no statistical differences between the two groups. Blood lactate: NF group is higher at 60min after MSI than the other groups (P<0.05). Hct:NS group is lower than...