The Expression And Regulation Of Nod2 Receptor In Human Airway Epithelial Cells

Recently more and more researchers pay their attentions to the innate immunity, which is a critical interface that protects the host from infection by various pathogens and important of organism to exist. Innate immunity and adaptive immunity make up the most significant defence system in human beings.Pathogen-associated molecular patterns are conservative ingredients which is necessary to exist for causative organism but don't present in host cells. In bacteria, examples of such PAMPs include lipopolysaccharide (LPS) , Hpoproteins, peptidoglycan and CpG DNA. These molecules can be detected by pattern recognition receptors, which are distributed on cell wall or in cytoplasm. The Toll-like receptors (TLRs), a family of membrane-anchored proteins, has been in the past few years the subject of intense investigation. More recently, the Nods, a new family of intracellular bacterial sensors, have been identified in the cytosol of various cells, such as epithelial cells and macrophages. Research on Nod2 has received attention since a genetic approach allowed the identification of Nod2 as the first susceptibility gene for Crohn's.Nod2 can detect peptidoglycan.Nod2 promoter contains NF- κB-response elements that enable the transcription activation of Nod2,following stimulation with TNF- α, IFN- γ and some invasive bacteria.