| Objective: It is a difficult problem to treat bone defect in clinical field. By now,some methods,such as bone transplantation could resolve this question partially,which still has some deficiency. New type biocomposite nano-hydroxyapatite/Chitosan is similar to human body bone,which supply a prosperous treating method. This study is to investigate the characteristics of nano-hydroxyapatite/Chitosan porous composite and explore the enfluence on osteoconductivity of nano-hydroxyapatite added to different chitosan from in vivo and in vitro experiments(animal experiment) in order to find a not only better efficacy of osteoconductivity but also better biomechanical materials.Method: 1. in vitro experiment,the compressive strengthen,porosity rate,porous diameter and relative degradation velocity in simulated body fluid are measured. 2. Animal experiment Twenty New Zealand white rabbits, each weighing approximately 2.0 to 2.5 kg, were used for this study. Three 10x5mm ostectomy was made on the middle of the each tibia of each... |
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