Effects Of Prostaglandin E1 On Diabetic Peripheral Neuropathy: A Systematic Review Of Randomized Evidence

Background: Peripheral neuropathy is the most common diabetic chronic complication and one cause of disabling. Up to now, there are no definitively effective treatments for diabetic peripheral neuropathy, and optimal glucose control is the fundamental treatment for preventing diabetic neuropathy from developing and for limiting its progression. However, the nerve function has not been completely improved in some patients who have suffered from this disease by optimal glucose control, and symptoms and signs have not been necessary improved. So other complementarity are necessary besides treatments must be administered based on the intensive control of blood glucose. Recently there have been many small-sample randomized clinical trials for the effects of Prostaglandin E1 on diabetic peripheral neuropathy. Some clinical trials suggested that Prostaglandin E1 improved the clinical symptoms and signs of diabetic peripheral neuropathy, increased the nerve conduction velocity, and improved the quality of life of the patients. But untill now, there have not been rigorously designs, randomized, double-blind, placebo-controlled trials approve that Prostaglandin E1 is effective and safe in the treatment of the patients with diabetic peripheral neuropathy.Objective: To review systematically whether there is enough existing evidence that Prostaglandin E1 is effective and safe in the treatment of the...