The Animal Model Study Of Streptococcal M6 Protein In Triggering Guttate Psoriasis

Background and objectiveIt was shown that the strongest association among Group A streptococcus (GAS) infection and onset of acute guttate psoriasis and aggravation of plaque psoriasis was exist. Streptococcal M6 protein may play an important role as a su-perantigen in the acute form of the disease. But the real pathogenesis of the disease is largely unknown. By a series of tests, we have previously shown that there are GAS - M protein expressions on the epidermis and dermal papilla of the patients with acute guttate psoriasis; A series of elevated titers of antistrepto-coccal M6 protein in different concentrations of serum from patients with guttate psoriasis but not in these with plaque psoriasis or the control group was found; M6 protein significantly increased proliferation of PBMC and the titers of inter-feron (IFN) -γ, but not interleukin (IL) -4 production by psoriatic PBMC, the balance of cytokines secretion of Thl/Th2 was disrupted. It is likely therefore that Streptococcus hemolyticus is responsible for the development of guttate psoriasis. Superantigen, especially the M6 protein may trigger the initiation of a-cute guttate psoriasis by stimulating PBMC of patients with acue guttate psoriasis. To further study the real pathogenesis of the function of streptococcal M6 protein in triggering guttate psoriasis, we would establish the psoriatic animal model of SCID mice with superantigen M6 protein.MethodsThe uninvolved full -thickness human skins (UFT skin) removed from the...