The Effect Of Sinomenine On The Proliferation, Apotosis And Gene Expression Of Cytokine Of THP-1 Cells

BackgroudRheumatoid arthritis (RA) is a common autoimmune chronic inflammatory joint disease,characterized by macrophage and lymphocyte infiltration, proliferation of synovial fibroblasts, and joint destruction.The aetiology of RA is not clear.It is postulated that a genetically susceptible host is exposed to an unknown pathogen(antigen),and that this interaction gives rise to a persistent immunological response.Rheumatoid arthritis can affect any joint where cartilage overlies bone and with a joint cavity lined by synovial membrane that contains synovial fluid.The changes to the synovium.the primary site of pathology,is crucial to the inflammatory process that occurs in RA.Monocyte-macrophages are critically involved in the pathogenesis of RA. Not only do they produce a variety of pro-inflammatory cytokines and chemokines, but they also contribute to the cartilage and bone destruction in RA through multiple mechanisms.In traditional Chinese medicine,rheumatoid arthritis is congruent with arthritis is called "Bi syndrome. "Bi syndrome manifests as pain, soreness, or numbness of muscles, tendons and joints,and is the result of the body being "invaded" by the external climatological factors of Wind,Cold, Heat, and/or Dampness.The symptoms...