Laboratory Study Of Effects Of YiFuning Soft Gelatin Capsules On Postmenopausal Hyperlipidemia In Experimental Rat

Background and Objectives:The woman in menopause will appear a series of physiological changes such as climacteric period syndromes (CS), lipid metabolism disorder, hypertension, osteoporosis, the atrophy of reproductive organ, etc, which is due to the decline of ovary function and decrease of estradiol level. The incidence rate of cardiovascular diseases increase obviously, among them atherosclerosis (AS) and coronary heart disease (CHD) are the main cause of death for women at present, which partly relates with hormonoprivia in postmenopause. The blood fat of menopausal woman mainly shows increase of total cholesterol (TC) and low density lipoprotein - cholesterol (LDL-C), while decrease of high density lipoprotein - cholesterol (HDL-C). Hyperlipoidemia relates with AS and CHD closely and is considered as one of the primary dangerous factors of AS. Above all, the increase of TC and LDL-C, decrease of HDL-C are primary dangerous factors to induce AS and CHD.Estradiol can reduce the occurrence of CHD, because it can improve lipid metabolism and maintain the normal blood fat density and function at 30% ~ 50%;...