XRCC3 Polymorphisms And Susceptibilities To Esophageal, Cardia And Non-cardia Gastric Cancer

[Objectives]1.Searching for the risk factors and etiological clues of esophageal, cardia and non-cardia gastric cancers.2.To study the association between genetic polymorphisms of XRCC3 and susceptibility to esophageal, cardia and non-cardia gastric cancers, and to explore the interactions of genetic and environment factors in etiology of esophageal, cardia and non-cardia gastric cancers.[Methods]1.In the study of esophageal cancer, the case-control study based on community was conducted. The esophageal cancer group (n=150) consists of all patients who were diagnosed with primary esophageal cancer and were identified between September in 2002 and September in 2005. Based on a rolling-match of recruitment and taking the esophageal cancer cases as the reference, population controls (n=402)matched frequently by gender and age (±5y) were continuously recruited. Study subjects were more than 20years old, had census register in the locality and have been living in Tong,an for more than 10 years. And all patients had not received radiotherapy or chemotherapy. A structured questionnaire was administered face to face to all subjects, which contained questions on soci-demographic characteristics, residential history, life-long water drinking, diet, smoking habit, alcohol drinking, tea consumption, physical state and disease history, occupational history and family cancer history.2.In the study of cardia cancer, the case-control study with the common control group was conducted. The cardia cancer group (n=155) consists of all patients who were diagnosed with primary cardia cancer and were identified between April and November in 2001 from five hospitals. Based on a rolling-match non-cardia gastric...