Association Of Polymorphisms In TAP2 With HBV Infection In Chinese Population

Background: Hepatitis virus B (HBV) is an enveloped virus and causes acute or chronic infection in human being. There are 350 million people worldwide effected by infection with HBV. One-quarter to one-third of them are expected to develop progressive liver disease, including cirrhosis and primary liver cancer. As is known, susceptibility to infectious diseases is a complex process that depends on the balance between invasion of the pathogens and immunity of the hosts. Some studies show that pathogens and host genetic factors both play an important role in the control of infection and the development of disease. Host genetic backgrounds may account, at least in part, for the outcome of HBV infection. Objectives: Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of transporter associated with antigen processing 2 gene (TAP2) and the susceptibility to the infection of hepatitis virus B. Methods: DNA samples were obtained from 356 patients infected with HBV and from 326 control subjects matched with cases. Then The SNPs of patients were revealed by restriction fragment length polymorphisms (RFLP), the controls' by DNA sequencing. We used the software PHASE 1.0 to construct the haplotype of every individual. At last the unconditional Logistic regression model was used to analyze the statistical association of genotypes or haplotypes in two groups adjusted by gender and age. Results: There is a significant difference in the polymorphism of Codon651 between the healthy controls and patients infected with HBV in North Chinese Han people : P<0.05 OR=1.81...