Detection And Significance Of Factors Contributing To The Development Of Coronary Collaterals In Patients With Acute Coronary Syndrome

Objective The mechanisms contributing to the formation and development of coronary collaterals in patient with coronary artery disease still remained to be unclear. The present study was assigned as detecting prospectively the factors involving in the formation and development of coronary collaterals(CC) and their significance in patients with acute coronary syndrome (ACS).Methods 269 patients with clinically diagnosed ACS were consecutively enrolled into the present study and divided into two groups according to the presence of coronary collaterals by Rentrop classification from quantitative coronary angiography(QCA): Coronary collateral group(CC group, defined by Rentrop classification ≥ 2) and control group(defined by Retrop classification < 2). Serial venous blood samples were collected at admission for determining of high-sensitive C-reactive protein(hs-CRP), brain natriuretic peptide(BNP), cardiac troponin I(cTnI), vascular endothelial growth factor(VEGF) and endostatin(ES). Baseline left ventricular ejection fraction(LVEF) was determined by cardiac echo, and the Thrombolysis in Myocardial Infarction(TIMI) risk score was applicated to stratification of patients at high risk.