Research On Relationship Of Survivin Gene Expression With Proliferation And Apoptosis Of Choroidal Melanoma

Choroidal melanoma is the most common malignant intraocular tumor in adults, which originate from choroidal melanocytes, and has poor prognosis. It threaten visual loss, enucleation, and death from metastatic disease. Thus, a deeper understanding of the molecular mechanisms governing choroidal melanoma development is necessary. It is important to design more specific markers of metastatic and prognostic to diagnose and eventually cure metastatic choroidal melanoma. Molecular biology of tumors revealed that the imbalanced cell proliferation and apoptosis is an important mechanism of the tumorigenesis and progression. In recent years, the research of inhibitor apoptosis genes has been a hot topic in molecular oncology. Survivin is a new member of the IAPS(Inhibitor apoptosis of proteins) family. It regularly expresses in G2/M phase and suppresses the activity of caspase-3 and caspase-7 to inhibit cell apoptosis. It is also involved in regulation of proliferation and enlisting angiogenesis. At present, litter is known about...