| Background and objective:Amyotrophic Lateral Sclerosis (ALS) is a kind of degenerative disease of nervous system, which can both involve upper motor neuron (cerebrum, brain stem, spinal cord, et al) and lower motor neuron (cranial nerve nuclei and anterior horn cell of spinal cord), is the most common type of motor neuron disease (MND), etiology unknown, the most patients will die in three to five years after final diagnosis, and epidemiology show that the incidence rate of ALS is growing. Now the therapeutic effect of common treatment methods such as anti-exitotoxicity, cleaning free radical, immunotherapy and nerve protection are limited, searching for more effectivetreatment methods is urgent needs for clinical doctors in department of neurology.In recent years, accompany with unceasing progress in the basic research field of stem cells, stem cells transplantation is showing extensive application perspective in numerous territories such as life science, medicine and biology, gene engineering and so on, cytotherapy is becoming modus operandi in treating ALS. In 2000 American professor Gearhart and Kerr Bonn try to treat ALS by transplanting ESCs (embryonic stem cells) into CSF (cerebrospinal fluid) of rats with ALS, experiments show that movement function in paralyzed hind limb of rats with ALS recovered obviously. And 6% in stem cells migrate into spinal cord and express the surface-marking which is... |
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