Proteomics Change Between Pro-and Post-SCI And Study Of GFAP Nitrotyrosine

BackgroundMany factors can lead to spinal cord injury (SCI). After SCI, the mortor function of paitients decreases or lost totally and life quality decreases significantly. Now, study of SCI is one tough problem need to be solved urgently in neuroscience. With the completion of genome, studing of life science come into post-genome era. Proteomics and related subjects have showed a good tendency. It has excellent perspective in illness diagnosis, personal therapy, vaccine development and so on. But there is no report using proteomics methods to study proteomics change pro- and post-SCI.Second injury may play a main role in spinal cord injury (SCI). Oxidative inflammatory reaction results from ischemia and hypoxia in second injury. Nitrotyrosine is the indicator of NO mediated oxidative inflammatory reaction. Tyrosine nitration, as a post-translational protein modification, has important function in structural and functional changing of protein. So an good understanding of mechanisms underlying protein nitration after SCI will provide insights into the pathogenic mechanisms of inflammatory diseases and novel therapeutic strategies for limiting tissue inflammatory injury.Now tyrosine nitration study of skeleton proteins have found that tyrosine nitration of actin can lead to impaired actin polymerization. It will alter cell motility,...