The Primary Research On The Role Of Calcitonin Gene-related Peptide On Pathogenesis Of Motion Sickness In Rats

Motion sickness has been a constant puzzle of aerospace medicine related to its high incidence and unknown pathogenesis. With the development of aerospace technology, it becomes more urgent and important to prevention and treatment AS and SMS. In recent years, a important neurotransmitter—calcitonin gene-related peptide (CGRP) is detected in the efferent vestibular system. It not only can excite vestibular hair cell directly, but also has been closely linked to some center neurotransmitters in association with MS, for example acetylcholine, histamine and Ca²⁺. More important still, CGRP is an effective cerebral vasodilating agent so far. It can exert action on vestibule function by regulating blood flow of cerebral vessels including vestibular receptor. Body fluid shift is an important cause that results in motion sickness, related to change of vestibular function. And the CGRP content of plasma is detected to just change while body fluid shift. However, there is still no clear what role CGRP plays in the mechanism of motion sickness at present, especially in AS and SMS. To clarify the relationship between MS and CGRP, we investigated: 1 .established animal models of motion sickness; 2.tested the CGRP content of plasma in rats of motion sickness;3 .explored the changes of the expressions of CGRP of the efferent vestibular system and vestibular nuclei in rats.; 4. detected the changes of the expressions of CGRP of the efferent vestibular system and vestibular nuclei in rats subjected to 1-wk simulated microgravity; 5.explored the changes of the expression of calcitonin gene related peptide of the efferent vestibular system and vestibular nuclei motion sickness model rats after intragastric administration with anisodamine.Method and materialTo establish animal models of motion sickness through trapezoid stimulation pattern (acceleration: 10°/s², peak speed: 240°/s, rotated in peak speed for 5 min, then...