Analysis Of Coronary Calcification And Its Correlative Factors In Chronic Renal Failure Patients.

Backgroud and Objective: Coronary calcification is one of the major reasons for cardiovascular disease (CVD) mortilty, and multi-slice spiral computed tomography(MSCT) is the most simple, sensitive and harmless method. Coronary calcification results from many factors. The purpose of this study was to investigate the factors correlated to coronary calcification in chronic renal failure patients such as metabolism of calcium and phosphorus which was analyzed .Methods: The fifty-three patients were enrolled (Males/Females=25/28), whose endogenous creatinine clearance rate(Ccr)0～42ml/min. Primary disease: 16 patients were chronic glomerulonephritis, 19 patients were diabetic nephropathy (DN) and 18 patients were hypertention nephritis. Among these patients, 26 patients were undergoing common hemodialysis (M/F=13/13). 34 patients had CVD before (M/F=16/18). All patients didn't have severe infection, liver disease . Quantification of coronary artery calcification was determined by multi-slice spiral computed tomography (MSCT) in all collected chronic renal failure patients. Meanwhile, serum creatinine, calcium, phosphonium, magnesium, cholesterol, triglyceride, albumin, C-reactive protein (CRP), parathyroid hormone parathyrin (PTH) were analysis. Calcium-phosphorus product and Ccr need to be calculated. Grouping: 1. according to quantification of coronary artery calcification, we set calcification group and no- calcification group. 2. according to primary disease: we set chronic glomerulonephritis group, diabetic nephropathy group and hypertention nephritis group. 3. according to Ccr and K-DOQI guideline, we set CKD3～4 stage group, CKD5 stage...