The Relative Study Between Matrix Metalloproteinase-9, C-reactive Protein And Carotid Atherosclerosis In Type 2 Diabetes Patients And The Effect Of Rosiglitazone Treatment

Objective: Macroangiopathy is one of the major complication of type 2 diabetes mellitus (T2DM) and an important cause of morbidity and mortality in these patients. The pathological hallmarkers of this complication is atherosclerosis (AS). Recent studies have shown that T2DM and AS are chronic inflammatory diseases. Inflammatory factors play an important role in the development of T2DM AS. C-reactive protein(CRP),interleukin-6(IL-6)have been proposed to be nontraditional inflammatory markers.Inflammation can enhance the expression of matrix metalloproteinase-9(MMP-9) which can over degrade the major components of basement membrane of vascular wall-type IV collagen,which is the first step of vascular disease.MMP-9 can also cause acute macrovascular complication through increasing the unstability of the plaques.Rosiglitazone(RSG),as an oral insulin sensitizer in broad clinical use is the agonist of peroxisome prolixferator-activated receptor-gamma (PPAR- γ ) which regulate glucose and lipid metabolism through transcriptional mechanisms and improve insulin resistence(IR).Recent studies...