| Objective: Drug dependence is a chronic and relapsing disease, which is characterized by compulsive, out of control drug use despite severe negtive consequences. Drug abuse can lead to publice health and secure problems. has been a severe problem in the world.Morphine is the most widely abused illegal drugs .It was reported that there were multiple signal transduction pathways involved in the development of drug dependence. Ca-CaM-CaMK-CREB pathway was an important one among these.Sanqi(Panax notoginseng F.H.Chen), a kind of valuable Chinese traditional medicine, has its distinctive function on dispersing stasis, relieving pain and eliminating swelling. It is usually applied for the treatment of traumatic injury, cerebral ischemia and sequela of cerebral hemorrhage.PNS, as the main effective component of Sanqi, acts on anti-inflammation, anti-fibrosis and anti-cerebral artery sclerosis. It can reduce overload of calcium in cerebral neurous after injury, improve immunity, get rid of free radicals, etc. PNS can alleviate morphine withdrawal symptom, but the mechanism was unclear. The aim of the... |
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