Study On The Value Of Immunocytochemical Method For Early Laboratory Diagnosis Of Tuberculous Meningitis

Objective Tuberculous meningitis(TBM) is a central nervous system infection disease caused by Mycobacterium tuberculosis。It is a severe and frequently fatal event if delaying in diagnosis and treatment. It has the high rate of mutilation and fatality .Because of the catastrophic nature of the disease and because effective as well as specific chemotherapy is available for this potentially curable infectious disease, the key point of prognostic resides in the early diagnosis and antituberculosis treatment promptly. As the infected disease of CNS, confirmatory diagnosis depends on the demonstration of the causative agent of the disease. Therefore"gold standard"diagnosis of tuberculous meningitis is the method which can demonstrate the presence of M. tuberculosis in the CSF Specimens. Nevertheless The acid-fast bacilli are seldom demonstrated in CSF by Ziehl-Neelsen staining,only about 10%.The culture of M.tuberculosis is not only time-consuming, about 1～2 months, but also less sensitivity ,the sensitivity is only 20～30%. So search for a method of earlier diagnosis is a highly urgent lesson for clinicians in order to avoid delaying the antituberculosis treatment and prognosis. Immunocytological...