The Expression Of Cord Blood Basic Fibroblast Growth Factor And Vascular Endothelial Growth Factor In Preterm Infant

Objective: To explore the expression of cord blood basic fibroblast growth factor and vascular endothelial growth factor in preterm infant and its relationship and to compare with term infant Method: The VEGF and bFGF levels in cord blood were detected by ELSIA in 20 preterm infants and 20 term infants.Results: The bFGF level of cord blood [(0.474±0.086)ng/L] in the preterm infants groups were significantly lower than that of cord blood[(0.537±0.071)ng/L] in the term infants groups(P<0.05) . The VEGF level of cord blood[(0.154±0.009) ng/L] in the preterm infants groups were significantly lower than that of cord blood[(0.162±0.010) ng/L] in the term infants groups(P<0.05) . But we didn't found the correlation of the bFGF and VEGF level of cord blood in the preterm infants groups (r=0.800, P>0.05) .Dscussion: bFGF is widely expressed by embryonic tissues, in which it has both mitogenic and morphogenic actions. It has reported that which could stimulate the growth of cells from multiple mesoblast and neuroectoderm. Expression of VEGF during embryonic life has been documented in neuroectoderm, choroid plexus, kidney glomeruli, lung alveoli, adrenal cortex, cardiac myocytes, the highly vascularized placenta, and corpus luteum. The placenta, together with the fetal arterial and venous vascular endothelium, is responsible for the soluble bFGF in the fetal circulation. This study, applying a high-sensitivity bioassay, detected bFGF concentrations in the maternal circulation, however, in levels significantly lower than in the fetus or neonate, a finding possibly explained by the diversity of sources of bFGF production in the fetus. bFGF production has slowed down before birth at term. During angiogenesis bFGF and VEGF may exert a beneficial influence above and beyond induction of neovessel formation, namely, enhanced cytoprotection against complement-mediated vascular injury. It has been demonstrated that the angiogenic heparin-binding growth factors, bFGF and VEGF (also known as vascular permeability factor), induce an angiogenic response via a direct effect on endothelial cells and that by acting in concert they have a potent synergistic effect on the induction of angiogenesis in vitro and suggestively in vivo. Previous studies demonstrated interdependence of bFGF and VEGF so that in certain circumstances VEGF expression in EC can be modulated by bFGF. Human umbilical cord blood mononuclear cell is induced to endothelial cell by VEGF, bFGF and insulin-like growth factor.Conclusion: These findings suggest that the bFGF level of cord blood in the preterm infants groups were lower than that of cord blood in the term infants groups , due to the function of organ and system of preterm infant is immature and the VEGF and bFGF levels of preterm infants is significantly lower than that of term infants after birth. The VEGF levels of preterm infants is significantly lower than that of term infants, so the VEGF levels of preterm infants may be a useful objective biochemical marker of premature delivery.